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CAMKK2 Calcium/calmodulin-dependent protein kinase belonging to a proposed calcium-triggered signaling cascade involved in a number of cellular processes. Isoform 1, isoform 2 and isoform 3 phosphorylate CAMK1 and CAMK4. Isoform 3 phosphorylates CAMK1D. Isoform 4, isoform 5 and isoform 6 lacking part of the calmodulin- binding domain are inactive. Seems to be involved in hippocampal activation of CREB1. Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. 7 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Autophagy; CAMKK family; EC; Kinase, protein; Meta subfamily; Other group; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor)
Chromosomal Location of Human Ortholog: 12q24.31
Cellular Component: cytoplasm; cytosol; intracellular; nucleus
Molecular Function: calcium ion binding; calmodulin binding; calmodulin-dependent protein kinase activity; protein-tyrosine kinase activity
Biological Process: calcium-mediated signaling; MAPKKK cascade; peptidyl-serine phosphorylation; peptidyl-threonine phosphorylation; positive regulation of protein amino acid phosphorylation; positive regulation of protein kinase activity; positive regulation of transcription, DNA-dependent; protein amino acid autophosphorylation; protein amino acid phosphorylation; regulation of protein kinase activity
Reference #:  Q96RR4 (UniProtKB)
Alt. Names/Synonyms: calcium/calmodulin-dependent protein kinase beta; Calcium/calmodulin-dependent protein kinase kinase 2; calcium/calmodulin-dependent protein kinase kinase 2, beta; Calcium/calmodulin-dependent protein kinase kinase beta; CaM-kinase kinase 2; CaM-kinase kinase beta; CaM-KK 2; CaM-KK beta; CAMKK; CaMKK 2; CaMKK beta; CAMKK beta protein; CAMKK2; CAMKKB; KIAA0787; KKCC2; MGC15254
Gene Symbols: CAMKK2
Molecular weight: 64,746 Da
Basal Isoelectric point: 6.25  Predict pI for various phosphorylation states
CST Pathways:  AMPK Signaling
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Protein Structure Not Found.
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