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AurA a member of the AUR family of kinases. A cell cycle-regulated serine/threonine protein kinase that is overexpressed in many tumor cell lines. Regulated by phosphorylation-dependent proteasomal degradation. Localized to mitotic centrosomes and spindle microtubules and is required for centrosome maturation. Loss of Aurora A leads to defective mitotic spindles and gross errors in chromosome segregation. Required for centrosome duplication and chromosome segregation. Overexpression in culture drives transformation and aneuploidy, and negatively regulates p53. Amplified or overexpressed in many tumors or cell lines. Found as a skin tumor susceptibility gene in mouse, and a human SNP in a degradation domain is weakly cancer-associated and undergoes allele-specific amplification. Inhibitors: VX-680, ZM447439, Hesperadin, SNS-595. Note: This description may include information from UniProtKB.
Protein type: AUR family; EC; Kinase, protein; Oncoprotein; Other group; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor)
Chromosomal Location of Human Ortholog: 20q13.2
Cellular Component: centrosome; condensed nuclear chromosome, pericentric region; cytosol; microtubule cytoskeleton; midbody; nucleoplasm; nucleus; perinuclear region of cytoplasm; spindle; spindle microtubule; spindle midzone; spindle pole centrosome
Molecular Function: histone serine kinase activity; protein binding; protein heterodimerization activity; protein kinase activity; protein kinase binding; protein serine/threonine kinase activity; protein serine/threonine/tyrosine kinase activity
Biological Process: anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; G2/M transition of mitotic cell cycle; mitotic cell cycle; mitotic spindle organization and biogenesis; negative regulation of protein binding; positive regulation of mitosis; protein amino acid autophosphorylation; protein amino acid phosphorylation; protein ubiquitination during ubiquitin-dependent protein catabolic process; regulation of centrosome cycle; regulation of cytokinesis; regulation of protein stability; response to wounding; spindle organization and biogenesis
Disease: Colorectal Cancer
Reference #:  O14965 (UniProtKB)
Alt. Names/Synonyms: AIK; ARK-1; ARK1; AURA; AURKA; Aurora A; Aurora kinase A; Aurora-related kinase 1; aurora/IPL1-like kinase; Aurora/IPL1-related kinase 1; AURORA2; Breast tumor-amplified kinase; breast-tumor-amplified kinase; BTAK; hARK1; IPL1-related kinase; MGC34538; serine/threonine kinase 6; serine/threonine protein kinase 15; Serine/threonine-protein kinase 15; Serine/threonine-protein kinase 6; Serine/threonine-protein kinase aurora-A; STK15; STK6; STK7
Gene Symbols: AURKA
Molecular weight: 45,809 Da
Basal Isoelectric point: 9.45  Predict pI for various phosphorylation states
CST Pathways:  G2/M DNA Damage Checkpoint
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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