Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage Cell Signaling Technology
Home | Login
About PhosphoSiteUsing PhosphoSiteprivacy & cookiesCuration ProcessContact
logos LINCs Logo Mt Sinai Logo NIH Logo NCI Logo
Search / Browse Functions
Protein Page:

USP18 Can efficiently cleave only ISG15 fusions including native ISG15 conjugates linked via isopeptide bonds. Necessary to maintain a critical cellular balance of ISG15-conjugated proteins in both healthy and stressed organisms. Belongs to the peptidase C19 family. Note: This description may include information from UniProtKB.
Protein type: EC 3.1.2.-; EC 3.4.19.-; Protease; Ubiquitin-specific protease
Chromosomal Location of Human Ortholog: 22q11.21
Cellular Component: cytosol; nucleus
Molecular Function: ISG15-specific protease activity; protein binding; ubiquitin-specific protease activity
Biological Process: protein deubiquitination; regulation of inflammatory response
Disease: Pseudo-torch Syndrome 2
Reference #:  Q9UMW8 (UniProtKB)
Alt. Names/Synonyms: 43 kDa ISG15-specific protease; hUBP43; ISG15-specific-processing protease; ISG43; ubiquitin specific peptidase 18; ubiquitin specific protease 18; Ubl carboxyl-terminal hydrolase 18; Ubl thioesterase 18; UBP18; UBP43; USP18
Gene Symbols: USP18
Molecular weight: 43,011 Da
Basal Isoelectric point: 8.05  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below


Protein Structure Not Found.
Download PyMol Script
Download ChimeraX Script

STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Scansite  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB