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AurB a member of the AUR family of kinases. May be directly involved in regulating the cleavage of polar spindle microtubules and is a key regulator for the onset of cytokinesis during mitosis. Expressed during S and G2/M phase and expression is upregulated in cancer cells during M phase. Localized to the midzone of central spindle in late anaphase and concentrated into the midbody in telophase and cytokinesis. Colocalizes with gamma tubulin in the mid-body. Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Overexpressed in colorectal and other cancer cell lines and thought to cause aneuploidy via histone phosphorylation. Note: This description may include information from UniProtKB.
Protein type: AUR family; EC; Kinase, protein; Other group; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor)
Chromosomal Location of Human Ortholog: 17p13.1
Cellular Component: condensed nuclear chromosome, pericentric region; cytosol; kinetochore; midbody; nucleoplasm; nucleus; spindle; spindle microtubule; spindle midzone; spindle pole centrosome
Molecular Function: histone serine kinase activity; protein binding; protein serine/threonine kinase activity; protein serine/threonine/tyrosine kinase activity
Biological Process: abscission; anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; attachment of spindle microtubules to kinetochore; histone modification; negative regulation of B cell apoptosis; negative regulation of cytokinesis; negative regulation of protein binding; negative regulation of transcription from RNA polymerase II promoter; positive regulation of cytokinesis; positive regulation of telomerase activity; positive regulation of telomere maintenance via telomerase; protein amino acid autophosphorylation; protein amino acid phosphorylation; protein sumoylation; protein ubiquitination during ubiquitin-dependent protein catabolic process; regulation of chromosome segregation; sister chromatid cohesion; spindle midzone assembly involved in mitosis; spindle organization and biogenesis
Reference #:  Q96GD4 (UniProtKB)
Alt. Names/Synonyms: AIK2; AIM-1; AIM1; ARK-2; ARK2; AurB; AURKB; aurkb-sv1; aurkb-sv2; Aurora B; Aurora kinase B; aurora kinase B-Sv1; aurora kinase B-Sv2; Aurora- and IPL1-like midbody-associated protein 1; aurora-1; aurora-B; Aurora-related kinase 2; Aurora/IPL1-related kinase 2; IPL1; serine/threonine kinase 12; Serine/threonine-protein kinase 12; Serine/threonine-protein kinase aurora-B; STK-1; STK12; STK5
Gene Symbols: AURKB
Molecular weight: 39,311 Da
Basal Isoelectric point: 9.36  Predict pI for various phosphorylation states
CST Pathways:  Microtubule Dynamics
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