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AurC a member of the AUR family of kinases. May play a part in organizing microtubules in relation to the function of the centrosome/spindle pole during mitosis. Localized to centrosome from anaphase to cytokinesis. Two splice-variant isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: AUR family; EC; Kinase, protein; Other group; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor)
Chromosomal Location of Human Ortholog: 19q13.43
Cellular Component: condensed chromosome; condensed nuclear chromosome, pericentric region; midbody; spindle; spindle microtubule; spindle midzone; spindle pole centrosome
Molecular Function: histone serine kinase activity; protein binding; protein kinase activity; protein serine/threonine/tyrosine kinase activity
Biological Process: attachment of spindle microtubules to kinetochore; histone modification; positive regulation of cytokinesis; protein amino acid phosphorylation; spindle midzone assembly involved in mitosis
Disease: Spermatogenic Failure 5
Reference #:  Q9UQB9 (UniProtKB)
Alt. Names/Synonyms: AIE2; AIK3; ARK-3; ARK3; AurC; AURKC; Aurora C; Aurora kinase C; aurora-C; Aurora-related kinase 3; Aurora/IPL1-related kinase 3; Aurora/IPL1/Eg2 protein 2; serine/threonine kinase 13 (aurora/IPL1-like); Serine/threonine-protein kinase 13; Serine/threonine-protein kinase aurora-C; STK13
Gene Symbols: AURKC
Molecular weight: 35,591 Da
Basal Isoelectric point: 8.96  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

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