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Spinophilin actin-binding regulatory subunit of protein phosphatase 1 (PP1). The actin-binding domain of spinophilin is necessary and sufficient for targeting of spinophilin to dendrites and dendritic spines. May play a role in establishing a signaling complex for dopaminergic neurotransmission through D2 receptors by linking receptors downstream signaling molecules and the actin cytoskeleton. Interacts with p14-ARF. Contains one PDZ/DHR domain. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold; Protein phosphatase, regulatory subunit
Chromosomal Location of Human Ortholog: 17q21.33
Cellular Component: cytoplasm; filopodium; lamellipodium; nucleoplasm; plasma membrane; protein phosphatase type 1 complex
Molecular Function: protein binding
Biological Process: cell cycle arrest; cell migration; filopodium formation; negative regulation of cell growth; regulation of cell growth by extracellular stimulus
Reference #:  Q96SB3 (UniProtKB)
Alt. Names/Synonyms: FLJ30345; NEB2; neurabin II; Neurabin-2; Neurabin-II; PPP1R6; PPP1R9; PPP1R9B; Protein phosphatase 1 regulatory subunit 9B; protein phosphatase 1, regulatory (inhibitor) subunit 9B; protein phosphatase 1, regulatory subunit 9B; protein phosphatase 1, regulatory subunit 9B, spinophilin; SPINO; Spinophilin; SPL; Spn
Gene Symbols: PPP1R9B
Molecular weight: 89,192 Da
Basal Isoelectric point: 4.91  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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