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GAP43 This protein is associated with nerve growth. It is a major component of the motile growth cones that form the tips of elongating axons. Plays a role in axonal and dendritic filopodia induction. Identified in a complex containing FGFR4, NCAM1, CDH2, PLCG1, FRS2, SRC, SHC1, GAP43 and CTTN. Binds calmodulin with a greater affinity in the absence of Ca(2+) than in its presence. Belongs to the neuromodulin family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Cell surface
Chromosomal Location of Human Ortholog: 3q13.31
Cellular Component: filopodium membrane; plasma membrane; postsynaptic density
Molecular Function: protein binding
Biological Process: axon guidance; protein kinase C activation; regulation of filopodium formation; response to wounding
Reference #:  P17677 (UniProtKB)
Alt. Names/Synonyms: Axonal membrane protein GAP-43; B-50; calmodulin-binding protein P-57; GAP43; growth associated protein 43; Growth-associated protein 43; nerve growth-related peptide GAP43; NEUM; Neural phosphoprotein B-50; Neuromodulin; neuron growth-associated protein 43; pp46; protein F1
Gene Symbols: GAP43
Molecular weight: 24,803 Da
Basal Isoelectric point: 4.64  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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