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CLK3 a CMGC kinase of the CLK family. Phosphorylates serine- and arginine-rich (SR) proteins of the spliceosomal complex. May play a role in regulating RNA splicing. Three alternatively spliced isoforms have been described. Isoform 2 is short and lacks the kinase domain. May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. Note: This description may include information from UniProtKB.
Protein type: CLK family; CMGC group; EC; Kinase, protein; Protein kinase, CMGC; Protein kinase, dual-specificity (non-receptor)
Chromosomal Location of Human Ortholog: 15q24.1
Cellular Component: intermediate filament cytoskeleton; membrane; nucleoplasm; nucleus
Molecular Function: identical protein binding; protein binding; protein serine/threonine kinase activity; RNA binding
Biological Process: protein amino acid phosphorylation; regulation of RNA splicing
Reference #:  P49761 (UniProtKB)
Alt. Names/Synonyms: CDC-like kinase 3; CLK3; Dual specificity protein kinase CLK3; FLJ22858; PHCLK3; PHCLK3/152
Gene Symbols: CLK3
Molecular weight: 73,515 Da
Basal Isoelectric point: 9.94  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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