Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage Cell Signaling Technology
Home | Login
About PhosphoSiteUsing PhosphoSiteprivacy & cookiesCuration ProcessContact
logos LINCs Logo Mt Sinai Logo NIH Logo NCI Logo
Search / Browse Functions
Protein Page:

CDK11B a protein kinase of the CDK family. May act as a negative regulator of the normal cell cycle progression. Nine alternatively spliced isoforms have been described. The p110 isoforms have been suggested to be involved in pre-mRNA splicing, potentially by phosphorylating the splicing protein SFRS7. The p58 isoform is specifically induced in G2/M phase of the cell cycle. 2 isoforms, SV9 and 7, are produced by alternative initiation at Met-1 and Met-357 resulting in p110 and p58 isoforms, respectively. Deleted or altered frequently in neuroblastoma with amplified MYCN genes. Can be cleaved by caspases and demonstrated to play a role in cell apoptosis. Note: This description may include information from UniProtKB.
Protein type: Apoptosis; CDK family; CDK/PITSLRE subfamily; CMGC group; Cell cycle regulation; EC; Kinase, protein; Motility/polarity/chemotaxis; PITSLRE subfamily; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor)
Chromosomal Location of Human Ortholog: 1p36.33
Cellular Component: nucleus
Molecular Function: ATP binding; cyclin-dependent protein kinase activity; protein binding; protein kinase activity; protein serine/threonine kinase activity; RNA binding
Biological Process: cell proliferation; protein amino acid phosphorylation; regulation of cell growth; regulation of mitotic cell cycle; regulation of mRNA processing
Reference #:  P21127 (UniProtKB)
Alt. Names/Synonyms: CD11B; CDC-related protein kinase p58; CDC2L1; CDC2L2; CDK11; CDK11-p110; CDK11-p46; CDK11-p58; CDK11B; CDK11p58; cell division cycle 2-like 1 (PITSLRE proteins); cell division cycle 2-like 2 (PITSLRE proteins); cell division cycle 2-like protein kinase 1; cell division protein kinase 11B; CLK-1; cyclin-dependent kinase 11B; FLJ59152; galactosyltransferase-associated protein kinase p58/GTA; p58; p58 CLK-1; p58CDC2L1; p58CLK-1; PITSLRE; PITSLRE serine/threonine-protein kinase CDC2L1; PITSLREA; PK58
Gene Symbols: CDK11B
Molecular weight: 92,707 Da
Basal Isoelectric point: 5.45  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below


Protein Structure Not Found.

STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Scansite  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene