a protein kinase of the CDK family. May act as a negative regulator of the normal cell cycle progression. Nine alternatively spliced isoforms have been described. The p110 isoforms have been suggested to be involved in pre-mRNA splicing, potentially by phosphorylating the splicing protein SFRS7. The p58 isoform is specifically induced in G2/M phase of the cell cycle. 2 isoforms, SV9 and 7, are produced by alternative initiation at Met-1 and Met-357 resulting in p110 and p58 isoforms, respectively. Deleted or altered frequently in neuroblastoma with amplified MYCN genes. Can be cleaved by caspases and demonstrated to play a role in cell apoptosis. Note: This description may include information from UniProtKB.
Protein type: Apoptosis; CDK family; CDK/PITSLRE subfamily; CMGC group; Cell cycle regulation; EC 126.96.36.199; Kinase, protein; Motility/polarity/chemotaxis; PITSLRE subfamily; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor)