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CDK12 a Ser/Thr protein kinase of the CMGC group and CDK family. Phosphorylates the C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit RPB1, thereby acting as a key regulator of transcription elongation. Required for RNA splicing, possibly by phosphorylating SRSF1/SF2. Interacts with CCNL1 and CCNL2. Colocalized with nuclear speckles throughout interphase. Has a highly phosphorylated arginine/serine-rich (RS) domain N-terminal to the kinase domain. Chromosomal aberrations involving CDK12 may be a cause gastric cancer. Deletions within 17q12 region producing fusion transcripts with ERBB2, leading to CDK12-ERBB2 fusion leading to trunctated CDK12 protein not in-frame with ERBB2. Three isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: CDK family; CDK/CRK7 subfamily; CMGC group; CRK7 subfamily; Cell cycle regulation; EC; EC; Kinase, protein; Motility/polarity/chemotaxis; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor); RNA splicing; Spliceosome
Chromosomal Location of Human Ortholog: 17q12
Cellular Component: chromosome; fibrillar center; nuclear cyclin-dependent protein kinase holoenzyme complex; nuclear speck; nucleoplasm; nucleus; transcription elongation factor complex b
Molecular Function: cyclin binding; cyclin-dependent protein kinase activity; protein binding; protein kinase activity; RNA polymerase subunit kinase activity; transcription factor binding
Biological Process: positive regulation of transcription from RNA polymerase II promoter; protein amino acid autophosphorylation; regulation of MAP kinase activity; RNA elongation from RNA polymerase II promoter; RNA splicing
Reference #:  Q9NYV4 (UniProtKB)
Alt. Names/Synonyms: Cdc2-related kinase, arginine/serine-rich; CDC2-related protein kinase 7; CDK12; Cell division cycle 2-related protein kinase 7; Cell division protein kinase 12; CRK7; CRKR; CRKRS; cyclin-dependent kinase 12; KIAA0904
Gene Symbols: CDK12
Molecular weight: 164,155 Da
Basal Isoelectric point: 9.46  Predict pI for various phosphorylation states
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Protein Structure Not Found.
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