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NKD2 Cell autonomous antagonist of the canonical Wnt signaling pathway. May activate a second Wnt signaling pathway that controls planar cell polarity. Required for processing of TGFA and for targeting of TGFA to the basolateral membrane of polarized epithelial cells. Interacts with DVL1, DVL2, DVL3 and PPP2R3A. Interacts with RNF25 and TGFA (via cytoplasmic domain). Expressed in kidney, lung, pancreas and spleen. Belongs to the NKD family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Cell development/differentiation; Ubiquitin conjugating system
Chromosomal Location of Human Ortholog: 5p15.33
Cellular Component: basolateral plasma membrane; cytoplasmic vesicle; lateral plasma membrane; plasma membrane
Molecular Function: ATPase binding; growth factor binding; myosin heavy chain binding; protein binding; ubiquitin protein ligase binding
Biological Process: Golgi vesicle fusion to target membrane; positive regulation of proteasomal ubiquitin-dependent protein catabolic process
Reference #:  Q969F2 (UniProtKB)
Alt. Names/Synonyms: Dvl-binding protein NKD2; hNkd2; naked cuticle homolog 2 (Drosophila); naked cuticle-2; Naked-2; Naked2; NKD2; Protein naked cuticle homolog 2
Gene Symbols: NKD2
Molecular weight: 50,055 Da
Basal Isoelectric point: 7.83  Predict pI for various phosphorylation states
CST Pathways:  Wnt/ß-Catenin Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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