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NKD1 Cell autonomous antagonist of the canonical Wnt signaling pathway. May activate a second Wnt signaling pathway that controls planar cell polarity. Interacts with DVL1, DVL2, DVL3 and PPP2R3A. Expression is induced by activation of the Wnt signaling pathway. Expressed in colon, heart, kidney, leukocyte, liver, lung, ovary, pancreas, placenta, prostate, skeletal muscle, small intestine and spleen. Belongs to the NKD family. Note: This description may include information from UniProtKB.
Protein type: Cell development/differentiation
Chromosomal Location of Human Ortholog: 16q12.1
Cellular Component: cytoplasm; protein phosphatase type 2A complex
Molecular Function: protein binding
Biological Process: eye photoreceptor cell differentiation; positive regulation of protein catabolic process; somatic muscle development
Reference #:  Q969G9 (UniProtKB)
Alt. Names/Synonyms: Dvl-binding protein; hNkd; hNkd1; naked cuticle homolog 1 (Drosophila); naked cuticle-1; Naked-1; Naked1; NKD; NKD1; Protein naked cuticle homolog 1
Gene Symbols: NKD1
Molecular weight: 52,285 Da
Basal Isoelectric point: 8.82  Predict pI for various phosphorylation states
CST Pathways:  Wnt/ß-Catenin Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

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