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QIK a serine/threonine kinase of the CAMKL family and related to AMPK. Specifically expressed in adipose tissues. Like AMPK, QIK is phosphorylated and activated by LKB1. Part of a molecular complex including TORC2 and calcineurin that regulates the effects of circulating glucose and gut hormones during feeding on TORC2-mediated gene expression. In mice, insulin promotes the phosphorylation and ubiquitin-dependent degradation of TORC2, inhibiting gluconeogenic gene expression during re-feeding. In response to insulin, Akt2 phosphorylates and activates QIK which in turn stimulates the phosphorylation and cytoplasmic translocation of TORC2 where it associates with COP1, which promotes its ubiquitination and proteasomal degradation. Phosphorylates Ser794 of IRS1 in insulin-stimulated adipocytes, potentially modulating the efficiency of insulin signal transduction. Inhibits CREB activity by phosphorylating and repressing the CREB-specific coactivators, CRTC1-3. Note: This description may include information from UniProtKB.
Protein type: CAMK group; CAMKL family; EC; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor); QIK subfamily
Chromosomal Location of Human Ortholog: 11q23.1
Cellular Component: cytoplasm; nucleus
Molecular Function: ATP binding; magnesium ion binding; protein binding; protein serine/threonine kinase activity
Biological Process: cellular response to hormone stimulus; protein amino acid autophosphorylation; protein amino acid phosphorylation; regulation of insulin receptor signaling pathway
Reference #:  Q9H0K1 (UniProtKB)
Alt. Names/Synonyms: DKFZp434K1115; KIAA0781; LOH11CR1I; QIK; Qin-induced kinase; salt-inducible kinase 2; Salt-inducible protein kinase 2; salt-inducible serine/threonine kinase 2; Serine/threonine-protein kinase SIK2; Serine/threonine-protein kinase SNF1-like kinase 2; SIK-2; SIK2; SNF1-like kinase 2; SNF1LK2
Gene Symbols: SIK2
Molecular weight: 103,915 Da
Basal Isoelectric point: 5.7  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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