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MARK2 a CAMK protein kinase of the CAMKL group. Plays a role in epithelial morphogenesis. Modulates the developmental decision to build a columnar versus a hepatic epithelial cell apparently by promoting a switch from a direct to a transcytotic mode of apical protein delivery. Essential for the asymmetric development of membrane domains of polarized epithelial cells. One or more isoforms may play a role in graft rejection. 12 isoforms of the human protein are produced by alternative promoter. Note: This description may include information from UniProtKB.
Protein type: CAMK group; CAMKL family; EC; EC; Kinase, protein; MARK subfamily; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor)
Chromosomal Location of Human Ortholog: 11q13.1
Cellular Component: actin filament; lateral plasma membrane; membrane; nucleoplasm; plasma membrane
Molecular Function: ATP binding; cadherin binding; magnesium ion binding; protein binding; protein kinase activator activity; protein serine/threonine kinase activity; RNA binding; tau-protein kinase activity
Biological Process: activation of protein kinase activity; establishment and/or maintenance of epithelial cell polarity; establishment of cell polarity; neuron migration; peptidyl-threonine phosphorylation; protein amino acid autophosphorylation; protein amino acid phosphorylation; regulation of axonogenesis; regulation of cytoskeleton organization and biogenesis
Reference #:  Q7KZI7 (UniProtKB)
Alt. Names/Synonyms: ELKL motif kinase 1; EMK-1; EMK1; MAP/microtubule affinity-regulating kinase 2; MARK2; MGC99619; PAR-1; PAR1 homolog; Par1b; Ser/Thr protein kinase PAR-1B; serine/threonine protein kinase EMK; Serine/threonine-protein kinase MARK2
Gene Symbols: MARK2
Molecular weight: 87,911 Da
Basal Isoelectric point: 9.73  Predict pI for various phosphorylation states
CST Pathways:  Microtubule Dynamics  |  Wnt/ß-Catenin Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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