a CAMK protein kinase of the CAMKL group. Plays a role in epithelial morphogenesis. Modulates the developmental decision to build a columnar versus a hepatic epithelial cell apparently by promoting a switch from a direct to a transcytotic mode of apical protein delivery. Essential for the asymmetric development of membrane domains of polarized epithelial cells. One or more isoforms may play a role in graft rejection. 12 isoforms of the human protein are produced by alternative promoter. Note: This description may include information from UniProtKB.
Protein type: CAMK group; CAMKL family; EC 22.214.171.124; EC 126.96.36.199; Kinase, protein; MARK subfamily; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor)
Molecular Function: ATP binding; cadherin binding; magnesium ion binding; protein binding; protein kinase activator activity; protein serine/threonine kinase activity; RNA binding; tau-protein kinase activity
Biological Process: activation of protein kinase activity; establishment and/or maintenance of epithelial cell polarity; establishment of cell polarity; neuron migration; peptidyl-threonine phosphorylation; protein amino acid autophosphorylation; protein amino acid phosphorylation; regulation of axonogenesis; regulation of cytoskeleton organization and biogenesis