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VMP1 Stress-induced protein that, when overexpressed, promotes formation of intracellular vacuoles followed by cell death. May be involved in the cytoplasmic vacuolization of acinar cells during the early stage of acute pancreatitis. Plays a role in the initial stages of the autophagic process through its interaction with BECN1. Involved in cell-cell adhesion. Plays an essential role in formation of cell junctions. Interacts with BECN1. Interacts with TJP1. Interacts with TP53INP2. Belongs to the VMP1 family. Note: This description may include information from UniProtKB.
Protein type: Endoplasmic reticulum; Membrane protein, integral; Membrane protein, multi-pass
Chromosomal Location of Human Ortholog: 17q23.1
Cellular Component: endoplasmic reticulum; membrane; nucleolus
Molecular Function: protein binding
Biological Process: cell-cell adhesion; endoplasmic reticulum organization and biogenesis; exocytosis; Golgi organization and biogenesis
Reference #:  Q96GC9 (UniProtKB)
Alt. Names/Synonyms: DKFZp566I133; TDC1; TMEM49; TMM49; Transmembrane protein 49; Vacuole membrane protein 1; VMP1
Gene Symbols: VMP1
Molecular weight: 46,238 Da
Basal Isoelectric point: 6.47  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

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