a protein kinase of the CAMK2 family. A prominent kinase in the central nervous system that may function in long-term potentiation and neurotransmitter release. Member of the NMDAR signaling complex in excitatory synapses that may regulate NMDAR-dependent potentiation of the AMPAR and synaptic plasticity. The holoenzyme is composed of four different chains: alpha, beta, gamma, and delta. The different chains assemble into homo- or heteromultimeric holoenzymes composed of 8 to 12 subunits. May interact with BAALC, MPDZ, SYN1 and synGAP. 4 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: CAMK group; CAMK2 family; EC 22.214.171.124; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor)
Molecular Function: ATP binding; calcium-dependent protein serine/threonine phosphatase activity; calmodulin binding; calmodulin-dependent protein kinase activity; identical protein binding; protein binding; protein homodimerization activity; protein serine/threonine kinase activity; Ras guanyl-nucleotide exchange factor activity
Biological Process: calcium ion transport; cell differentiation; G1/S transition of mitotic cell cycle; insulin secretion; MAPK cascade; nervous system development; peptidyl-serine phosphorylation; peptidyl-threonine phosphorylation; protein amino acid dephosphorylation; protein autophosphorylation; protein oligomerization; regulation of calcium ion transport; regulation of cellular response to heat; regulation of molecular function; regulation of skeletal muscle adaptation
Alt. Names/Synonyms: calcium/calmodulin-dependent protein kinase (CaM kinase) II gamma; calcium/calmodulin-dependent protein kinase II gamma; Calcium/calmodulin-dependent protein kinase type II subunit gamma; CaM kinase II subunit gamma; CAMK; CAMK-II; CaMK-II subunit gamma; CAMK2G; CAMKG; CaMKII; FLJ16043; KCC2G; MGC26678