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DUSP3 a non-receptor, dual-specificity phosphoprotein phosphatase (DUSP). Different members of the DUSP family show distinct substrate specificities for MAPKs, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. DUSP3 inactivates the mitogen-activated kinases Erk2 and Jnk and is phosphorylated by ZAP-70. Phosphorylation by ZAP-70 is required for DUSP3 to inhibit the Erk2-Elk-1 pathway. Note: This description may include information from UniProtKB.
Protein type: EC; EC; Motility/polarity/chemotaxis; Protein phosphatase, dual-specificity
Chromosomal Location of Human Ortholog: 17q21.31
Cellular Component: cytosol; immunological synapse; nucleoplasm; nucleus
Molecular Function: MAP kinase phosphatase activity; phosphoric monoester hydrolase activity; protein kinase binding; protein tyrosine phosphatase activity; protein tyrosine/serine/threonine phosphatase activity
Biological Process: dephosphorylation; inactivation of MAPK activity; negative regulation of JNK cascade; negative regulation of MAPKKK cascade; negative regulation of T cell activation; negative regulation of T cell receptor signaling pathway; positive regulation of mitotic cell cycle
Reference #:  P51452 (UniProtKB)
Alt. Names/Synonyms: dual specificity phosphatase 3; Dual specificity protein phosphatase 3; Dual specificity protein phosphatase VHR; DUS3; DUSP3; serine/threonine specific protein phosphatase; vaccinia virus phosphatase VH1-related; VHR
Gene Symbols: DUSP3
Molecular weight: 20,478 Da
Basal Isoelectric point: 7.66  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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