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Ku80 the 80-kilodalton subunit of the Ku complex, also known as ATP-dependant DNA helicase II. A single stranded DNA-dependent ATP-dependent helicase. It functions together with the DNA ligase IV-XRCC4 complex in the repair of DNA double-strand break by non-homologous end joining and the completion of V(D)J recombination events. This gene functionally complements Chinese hamster xrs-6, a mutant defective in DNA double-strand break repair and in ability to undergo V(D)J recombination. A rare microsatellite polymorphism in this gene is associated with cancer in patients of varying radiosensitivity. Has a role in chromosome translocation. The DNA helicase II complex binds preferentially to fork-like ends of double-stranded DNA in a cell cycle-dependent manner. It works in the 3'-5' direction. Binding to DNA may be mediated by p70. Note: This description may include information from UniProtKB.
Protein type: DNA-binding; EC 3.6.1.-; EC 3.6.4.-; Helicase; Nuclear receptor co-regulator; Nucleolus; RNA-binding
Chromosomal Location of Human Ortholog: 2q35
Cellular Component: cytosol; extracellular region; membrane; nuclear chromosome, telomeric region; nuclear telomere cap complex; nucleoplasm; nucleus; plasma membrane; protein complex
Molecular Function: 5'-deoxyribose-5-phosphate lyase activity; double-stranded DNA binding; double-stranded telomeric DNA binding; enzyme activator activity; protein binding; protein C-terminus binding; RNA binding; telomeric DNA binding; ubiquitin protein ligase binding
Biological Process: double-strand break repair; double-strand break repair via nonhomologous end joining; negative regulation of transcription, DNA-dependent; neutrophil degranulation; positive regulation of catalytic activity; positive regulation of interferon type I production; positive regulation of protein kinase activity; positive regulation of telomerase activity; positive regulation of telomere maintenance via telomerase; regulation of smooth muscle cell proliferation; regulation of telomere maintenance
Reference #:  P13010 (UniProtKB)
Alt. Names/Synonyms: 86 kDa subunit of Ku antigen; ATP-dependent DNA helicase 2 subunit 2; ATP-dependent DNA helicase II 80 kDa subunit; CTC box-binding factor 85 kDa subunit; CTC85; CTCBF; DNA repair protein XRCC5; FLJ39089; G22P2; KARP-1; KARP1; Ku autoantigen, 80kD); Ku autoantigen, 80kDa; Ku80; Ku86; Ku86 autoantigen related protein 1; KUB2; Lupus Ku autoantigen protein p86; NFIV; Nuclear factor IV; Thyroid-lupus autoantigen; TLAA; X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining; X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining); X-ray repair cross-complementing protein 5; X-ray repair, complementing defective, repair in Chinese hamster; XRCC5
Gene Symbols: XRCC5
Molecular weight: 82,705 Da
Basal Isoelectric point: 5.55  Predict pI for various phosphorylation states
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