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AGO3 Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs. Belongs to the argonaute family. Ago subfamily. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Translation; Translation initiation
Chromosomal Location of Human Ortholog: 1p34.3
Cellular Component: cytoplasm; cytosol; membrane; nucleoplasm
Molecular Function: double-stranded RNA binding; miRNA binding; protein binding; RNA binding; single-stranded RNA binding
Biological Process: miRNA-mediated gene silencing, miRNA loading onto RISC; miRNA-mediated gene silencing, mRNA cleavage; miRNA-mediated gene silencing, negative regulation of translation; miRNA-mediated gene silencing, production of miRNAs; mRNA catabolic process; phosphoinositide-mediated signaling; pre-microRNA processing; RNA secondary structure unwinding; RNA-mediated posttranscriptional gene silencing; Wnt receptor signaling pathway, calcium modulating pathway
Reference #:  Q9H9G7 (UniProtKB)
Alt. Names/Synonyms: AGO3; argonaute 3; Argonaute3; eIF-2C 3; eIF2C 3; EIF2C3; Eukaryotic translation initiation factor 2C 3; eukaryotic translation initiation factor 2C, 3; FLJ12765; hAgo3; MGC86946; Protein argonaute-3
Gene Symbols: AGO3
Molecular weight: 97,360 Da
Basal Isoelectric point: 9.26  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

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