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Ku70 a mini-chromosome maintenance protein, essential for the initiation of eukaryotic genome replication. Allows DNA to undergo a single round of replication per cell cycle. Required for the entry in S phase and for cell division. Note: This description may include information from UniProtKB.
Protein type: DNA repair, damage; DNA-binding; EC 3.6.4.-; EC 4.2.99.-; Helicase; Nuclear receptor co-regulator; RNA-binding
Chromosomal Location of Human Ortholog: 22q13.2
Cellular Component: cytosol; extracellular region; membrane; nuclear chromosome, telomeric region; nuclear telomere cap complex; nucleolus; nucleoplasm; nucleus; protein complex; transcription factor complex
Molecular Function: 5'-deoxyribose-5-phosphate lyase activity; double-stranded DNA binding; double-stranded telomeric DNA binding; protein binding; protein C-terminus binding; RNA binding
Biological Process: DNA ligation; double-strand break repair via nonhomologous end joining; negative regulation of transcription, DNA-dependent; neutrophil degranulation; positive regulation of interferon type I production; positive regulation of protein kinase activity; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; protein heterotetramerization; regulation of smooth muscle cell proliferation; telomere maintenance
Reference #:  P12956 (UniProtKB)
Alt. Names/Synonyms: 70 kDa subunit of Ku antigen; ATP-dependent DNA helicase 2 subunit 1; ATP-dependent DNA helicase II 70 kDa subunit; ATP-dependent DNA helicase II, 70 kDa subunit; CTC box binding factor 75 kDa subunit; CTC box-binding factor 75 kDa subunit; CTC75; CTCBF; DNA repair protein XRCC6; G22P1; Ku autoantigen p70 subunit; Ku autoantigen, 70kDa; Ku70; Lupus Ku autoantigen protein p70; ML8; thyroid autoantigen 70kD (Ku antigen); thyroid autoantigen 70kDa (Ku antigen); Thyroid-lupus autoantigen; thyroid-lupus autoantigen p70; TLAA; X-ray repair complementing defective repair in Chinese hamster cells 6; X-ray repair cross-complementing protein 6; XRCC6
Gene Symbols: XRCC6
Molecular weight: 69,843 Da
Basal Isoelectric point: 6.23  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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