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CD59 Potent inhibitor of the complement membrane attack complex (MAC) action. Acts by binding to the C8 and/or C9 complements of the assembling MAC, thereby preventing incorporation of the multiple copies of C9 required for complete formation of the osmolytic pore. This inhibitor appears to be species-specific. Involved in signal transduction for T-cell activation complexed to a protein tyrosine kinase. Defects in CD59 are the cause of CD59 deficiency (CD59D). Note: This description may include information from UniProtKB.
Protein type: Membrane protein, GPI anchor
Chromosomal Location of Human Ortholog: 11p13
Cellular Component: anchored component of external side of plasma membrane; cell surface; compact myelin; endoplasmic reticulum membrane; endoplasmic reticulum-Golgi intermediate compartment membrane; extracellular space; focal adhesion; Golgi membrane; membrane; plasma membrane; sarcolemma; transport vesicle; vesicle
Molecular Function: complement binding; protein binding
Biological Process: blood coagulation; cell activation; cell surface receptor signaling pathway; COPII vesicle coating; ER to Golgi vesicle-mediated transport; negative regulation of activation of membrane attack complex; negative regulation of apoptosis; neutrophil degranulation; positive regulation of T cell proliferation; regulation of complement activation
Disease: Hemolytic Anemia, Cd59-mediated, With Or Without Immune-mediated Polyneuropathy
Reference #:  P13987 (UniProtKB)
Alt. Names/Synonyms: 16.3A5; 1F5; 1F5 antigen; 20 kDa homologous restriction factor; CD59; CD59 antigen; CD59 antigen p18-20 (antigen identified by monoclonal antibodies 16.3A5, EJ16, EJ30, EL32 and G344); CD59 glycoprotein; CD59 molecule, complement regulatory protein; EJ16; EJ30; EL32; FLJ38134; FLJ92039; G344; HRF-20; HRF20; human leukocyte antigen MIC11; Ly-6-like protein; lymphocytic antigen CD59/MEM43; MAC-inhibitory protein; MAC-IP; MACIF; MEM43; MEM43 antigen; membrane attack complex (MAC) inhibition factor; Membrane attack complex inhibition factor; Membrane inhibitor of reactive lysis; MGC2354; MIC11; MIN1; MIN2; MIN3; MIRL; MSK21; p18-20; Protectin; surface anitgen recognized by monoclonal antibody 16.3A5; T cell-activating protein
Gene Symbols: CD59
Molecular weight: 14,177 Da
Basal Isoelectric point: 6.02  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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