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CASP7 Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly- 217' bond. Overexpression promotes programmed cell death. Heterotetramer that consists of two anti-parallel arranged heterodimers, each one formed by a 20 kDa (p20) and a 11 kDa (p11) subunit. Interacts with BIRC6/bruce. Highly expressed in lung, skeletal muscle, liver, kidney, spleen and heart, and moderately in testis. No expression in the brain. Inhibited by isatin sulfonamides. Belongs to the peptidase C14A family. 3 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Apoptosis; EC; Endoplasmic reticulum; Mitochondrial; Protease
Chromosomal Location of Human Ortholog: 10q25.3
Cellular Component: cytoplasm; cytosol; nucleoplasm; nucleus
Molecular Function: cysteine-type endopeptidase activity; cysteine-type peptidase activity; peptidase activity; protein binding
Biological Process: apoptosis; caspase activation via cytochrome c; proteolysis
Reference #:  P55210 (UniProtKB)
Alt. Names/Synonyms: Apoptotic protease Mch-3; CASP-7; CASP7; caspase 7 isoform delta; caspase 7, apoptosis-related cysteine peptidase; caspase 7, apoptosis-related cysteine protease; Caspase-7; Caspase-7 subunit p11; Caspase-7 subunit p20; CMH-1; ICE-LAP3; ICE-like apoptotic protease 3; Lice2 alpha/beta/gamma; MCH3
Gene Symbols: CASP7
Molecular weight: 34,277 Da
Basal Isoelectric point: 5.72  Predict pI for various phosphorylation states
CST Pathways:  Apoptosis Regulation  |  Death Receptor Signaling  |  ErbB/HER Signaling  |  Inhibition of Apoptosis
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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