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Calmodulin a calcium-binding small regulatory protein that mediates the control of a large number of enzymes by Ca(2+). Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number of protein kinases and phosphatases. Has four functional calcium-binding domains. Phosphorylation and ubiquitination result in a decreased activity. Note: This description may include information from UniProtKB.
Protein type: Calcium-binding; Protein phosphatase, regulatory subunit
Chromosomal Location of Human Ortholog: 14q32.11
Disease: Long Qt Syndrome 14; Ventricular Tachycardia, Catecholaminergic Polymorphic, 4
Reference #:  P0DP23 (UniProtKB)
Alt. Names/Synonyms: CALM; CALM1; CALM2; CALM3; CALML2; Calmodulin; calmodulin 1 (phosphorylase kinase, delta); calmodulin 2 (phosphorylase kinase, delta); calmodulin 3 (phosphorylase kinase, delta); CAM; CAM1; CAM2; CAM3; CAMB; CAMC; CAMI; CAMIII; DD132; PHKD; phosphorylase kinase, delta subunit
Gene Symbols: CALM1; CALM2; CALM3
Molecular weight: 16,838 Da
Basal Isoelectric point: 4.09  Predict pI for various phosphorylation states
CST Pathways:  Actin Dynamics  |  B Cell Receptor Signaling  |  ErbB/HER Signaling  |  T Cell Receptor Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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