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TRAIL-R3 Receptor for the cytotoxic ligand TRAIL. Lacks a cytoplasmic death domain and hence is not capable of inducing apoptosis. May protect cells against TRAIL mediated apoptosis by competing with TRAIL-R1 and R2 for binding to the ligand. Higher expression in normal tissues than in tumor cell lines. Highly expressed in peripheral blood lymphocytes, spleen, skeletal muscle, placenta, lung and heart. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, GPI anchor
Chromosomal Location of Human Ortholog: 8p21.3
Cellular Component: integral component of plasma membrane; plasma membrane
Molecular Function: TRAIL binding; transmembrane receptor activity; tumor necrosis factor-activated receptor activity
Biological Process: immune response; inflammatory response; multicellular organism development; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; regulation of apoptosis; regulation of cell proliferation; response to lipopolysaccharide; signal transduction; tumor necrosis factor-mediated signaling pathway
Reference #:  O14798 (UniProtKB)
Alt. Names/Synonyms: Antagonist decoy receptor for TRAIL/Apo-2L; CD263; DCR1; Decoy receptor 1; Decoy TRAIL receptor without death domain; decoy without an intracellular domain; LIT; Lymphocyte inhibitor of TRAIL; MGC149501; MGC149502; TNF related apoptosis-inducing ligand receptor 3; TNF related TRAIL receptor; TNF-related apoptosis-inducing ligand receptor 3; TNFRSF10C; TR10C; TRAIL receptor 3; TRAIL receptor without an intracellular domain; TRAIL-R3; TRAILR3; TRID; Tumor necrosis factor receptor superfamily member 10C; tumor necrosis factor receptor superfamily, member 10c, decoy without an intracellular domain
Gene Symbols: TNFRSF10C
Molecular weight: 27,407 Da
Basal Isoelectric point: 4.79  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

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