Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage Cell Signaling Technology
Home | Login
About PhosphoSiteUsing PhosphoSiteprivacy & cookiesCuration ProcessContact
logos LINCs Logo Mt Sinai Logo NIH Logo NCI Logo
Search / Browse Functions
Protein Page:

TRAIL-R3 Receptor for the cytotoxic ligand TRAIL. Lacks a cytoplasmic death domain and hence is not capable of inducing apoptosis. May protect cells against TRAIL mediated apoptosis by competing with TRAIL-R1 and R2 for binding to the ligand. Higher expression in normal tissues than in tumor cell lines. Highly expressed in peripheral blood lymphocytes, spleen, skeletal muscle, placenta, lung and heart. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, GPI anchor
Chromosomal Location of Human Ortholog: 8p21.3
Cellular Component: integral to plasma membrane; plasma membrane
Molecular Function: transmembrane receptor activity; tumor necrosis factor receptor activity
Biological Process: immune response; inflammatory response; multicellular organismal development; negative regulation of caspase activity; regulation of apoptosis; regulation of cell proliferation; response to lipopolysaccharide; signal transduction
Reference #:  O14798 (UniProtKB)
Alt. Names/Synonyms: Antagonist decoy receptor for TRAIL/Apo-2L; CD263; DCR1; Decoy receptor 1; Decoy TRAIL receptor without death domain; decoy without an intracellular domain; LIT; Lymphocyte inhibitor of TRAIL; MGC149501; MGC149502; TNF related apoptosis-inducing ligand receptor 3; TNF related TRAIL receptor; TNF-related apoptosis-inducing ligand receptor 3; TNFRSF10C; TR10C; TRAIL receptor 3; TRAIL receptor without an intracellular domain; TRAIL-R3; TRAILR3; TRID; Tumor necrosis factor receptor superfamily member 10C; tumor necrosis factor receptor superfamily, member 10c, decoy without an intracellular domain
Gene Symbols: TNFRSF10C
Molecular weight: 27,407 Da
Basal Isoelectric point: 4.79  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below


Protein Structure Not Found.

STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Scansite  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB