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CEACAM5 Cell surface glycoprotein that plays a role in cell adhesion and in intracellular signaling. Receptor for E.coli Dr adhesins. Homodimer. Binding of E.coli Dr adhesins leads to dissociation of the homodimer. Found in adenocarcinomas of endodermally derived digestive system epithelium and fetal colon. Belongs to the immunoglobulin superfamily. CEA family. Note: This description may include information from UniProtKB.
Protein type: Immunoglobulin superfamily; Membrane protein, GPI anchor; Membrane protein, integral
Chromosomal Location of Human Ortholog: 19q13.2
Cellular Component: basolateral plasma membrane; extracellular region; integral to plasma membrane; plasma membrane
Molecular Function: identical protein binding; protein homodimerization activity
Biological Process: C-terminal protein lipidation; homotypic cell-cell adhesion; leukocyte migration; negative regulation of apoptosis
Reference #:  P06731 (UniProtKB)
Alt. Names/Synonyms: Carcinoembryonic antigen; Carcinoembryonic antigen-related cell adhesion molecule 5; CD66e; CEA; CEACAM5; CEAM5; DKFZp781M2392; Meconium antigen 100
Gene Symbols: CEACAM5
Molecular weight: 76,795 Da
Basal Isoelectric point: 5.59  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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