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PLXNA3 Coreceptor for SEMA3A and SEMA3F. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance in the developing nervous system. Regulates the migration of sympathetic neurons, but not of neural crest precursors. Required for normal dendrite spine morphology in pyramidal neurons. May play a role in regulating semaphorin-mediated programmed cell death in the developing nervous system. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down-stream signaling events in the cytoplasm. Interacts with CBFA2T3/MTG16. Belongs to the plexin family. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral
Chromosomal Location of Human Ortholog: Xq28
Cellular Component: cell junction; intracellular membrane-bound organelle; membrane; nucleus; plasma membrane
Molecular Function: protein binding
Biological Process: branchiomotor neuron axon guidance; multicellular organismal development; regulation of axon extension involved in axon guidance
Reference #:  P51805 (UniProtKB)
Alt. Names/Synonyms: 6.3; HSSEXGENE; plexin 4; plexin A3; Plexin-4; Plexin-A3; PLXA3; PLXN3; PLXN4; PLXNA3; Semaphorin receptor SEX; SEX; Sex chromosome X transmembrane protein of HGF receptor family 3; XAP-6
Gene Symbols: PLXNA3
Molecular weight: 207,703 Da
Basal Isoelectric point: 7.06  Predict pI for various phosphorylation states
CST Pathways:  Actin Dynamics
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

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