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SNAP-25 a presynaptic plasma membrane protein involved in the regulation of neurotransmitter release. May play an important role in the synaptic function of specific neuronal systems. Part of the SNARE core complex containing SNAP25, VAMP2 and syntaxin 1A. Associates with proteins involved in vesicle docking and membrane fusion. Two alternatively spliced isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: Vesicle
Chromosomal Location of Human Ortholog: 20p12.2
Cellular Component: cytoplasm; cytosol; growth cone; membrane; neuron projection; plasma membrane; presynaptic membrane; SNARE complex; vesicle; voltage-gated potassium channel complex
Molecular Function: calcium-dependent protein binding; protein binding; SNAP receptor activity; syntaxin-1 binding
Biological Process: glutamate secretion; neurotransmitter secretion; neutrophil degranulation; regulation of insulin secretion; synaptic vesicle exocytosis; synaptic vesicle fusion to presynaptic membrane; synaptic vesicle priming
Disease: Myasthenic Syndrome, Congenital, 18
Reference #:  P60880 (UniProtKB)
Alt. Names/Synonyms: bA416N4.2; dJ1068F16.2; FLJ23079; resistance to inhibitors of cholinesterase 4 homolog; RIC-4; RIC4; SEC9; SNAP; SNAP-25; SNAP25; SNP25; SUP; Super protein; Synaptosomal-associated 25 kDa protein; Synaptosomal-associated protein 25; synaptosomal-associated protein, 25kDa
Gene Symbols: SNAP25
Molecular weight: 23,315 Da
Basal Isoelectric point: 4.66  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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