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PCSK1 Involved in the processing of hormone and other protein precursors at sites comprised of pairs of basic amino acid residues. Substrates include POMC, renin, enkephalin, dynorphin, somatostatin and insulin. Belongs to the peptidase S8 family. Furin subfamily. Note: This description may include information from UniProtKB.
Protein type: EC; Protease
Chromosomal Location of Human Ortholog: 5q15
Cellular Component: extracellular space
Molecular Function: serine-type endopeptidase activity
Biological Process: cell-cell signaling; metabolic process; peptide biosynthetic process; peptide hormone processing; proteolysis
Disease: Body Mass Index Quantitative Trait Locus 12; Proprotein Convertase 1/3 Deficiency
Reference #:  P29120 (UniProtKB)
Alt. Names/Synonyms: BMIQ12; NEC 1; NEC1; Neuroendocrine convertase 1; PC1; PC3; PCSK1; Prohormone convertase 1; prohormone convertase 3; Proprotein convertase 1; proprotein convertase subtilisin/kexin type 1; SPC3
Gene Symbols: PCSK1
Molecular weight: 84,152 Da
Basal Isoelectric point: 5.66  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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