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NOV Immediate-early protein likely to play a role in cell growth regulation. Belongs to the CCN family. Expression is down-regulated by WT1. Interacts with FBLN1. Note: This description may include information from UniProtKB.
Protein type: Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 8q24.12
Cellular Component: cytoplasm; extracellular region; gap junction; intracellular membrane-bound organelle; proteinaceous extracellular matrix
Molecular Function: heparin binding; integrin binding; Notch binding; protein binding
Biological Process: angiogenesis; cell adhesion mediated by integrin; cell-cell signaling; chondrocyte differentiation; negative regulation of cell growth; negative regulation of inflammatory response; negative regulation of insulin secretion; negative regulation of NF-kappaB import into nucleus; positive regulation of Notch signaling pathway; smooth muscle cell migration; smooth muscle cell proliferation
Reference #:  P48745 (UniProtKB)
Alt. Names/Synonyms: CCN family member 3; CCN3; IBP-9; IGF-binding protein 9; IGFBP-9; IGFBP9; Insulin-like growth factor-binding protein 9; nephroblastoma overexpressed gene; Nephroblastoma-overexpressed gene protein homolog; NOV; NOVH; Protein NOV homolog
Gene Symbols: NOV
Molecular weight: 39,162 Da
Basal Isoelectric point: 8.12  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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