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PDPN May be involved in cell migration and/or actin cytoskeleton organization. When expressed in keratinocytes, induces changes in cell morphology with transfected cells showing an elongated shape, numerous membrane protrusions, major reorganization of the actin cytoskeleton, increased motility and decreased cell adhesion. Required for normal lung cell proliferation and alveolus formation at birth. Induces platelet aggregation. Does not have any effect on folic acid or amino acid transport. Does not function as a water channel or as a regulator of aquaporin-type water channels. Belongs to the podoplanin family. 4 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral
Chromosomal Location of Human Ortholog: 1p36.21
Cellular Component: apical plasma membrane; basolateral plasma membrane; cell projection; cytoplasmic vesicle; cytosol; filopodium; filopodium membrane; integral to plasma membrane; lamellipodium; lipid raft; membrane; microvillus membrane; plasma membrane; ruffle
Molecular Function: amino acid transmembrane transporter activity; chaperone binding; chemokine binding; folic acid transporter activity; protein binding; receptor binding; water channel activity; water transporter activity
Biological Process: amino acid transport; cell morphogenesis; folic acid transport; lung development; lymph node development; lymphangiogenesis; negative regulation of apoptosis; negative regulation of cell proliferation; platelet activation; positive regulation of cell migration; positive regulation of cell motility; Rho protein signal transduction; water transport
Reference #:  Q86YL7 (UniProtKB)
Alt. Names/Synonyms: Aggrus; Glycoprotein 36; glycoprotein, 36-KD; GP36; Gp38; GP40; HT1A-1; hT1alpha-1; hT1alpha-2; lung type I cell membrane associated glycoprotein; lung type-I cell membrane-associated glycoprotein; lung type-I cell membrane-associated glycoprotein (T1A-2); OTS8; PA2.26; PA2.26 antigen; PDPN; Podoplanin; T1-alpha; T1A; T1A-2
Gene Symbols: PDPN
Molecular weight: 16,698 Da
Basal Isoelectric point: 4.37  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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