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SLC17A7 Mediates the uptake of glutamate into synaptic vesicles at presynaptic nerve terminals of excitatory neural cells. May also mediate the transport of inorganic phosphate. Belongs to the major facilitator superfamily. Sodium/anion cotransporter family. VGLUT subfamily. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family; Vesicle
Chromosomal Location of Human Ortholog: 7|7 B3
Cellular Component: cell; excitatory synapse; integral to membrane; integral to synaptic vesicle membrane; intracellular organelle; presynaptic active zone; synapse; synaptic vesicle; synaptic vesicle membrane
Molecular Function: extracellular-glutamate-gated chloride channel activity; inorganic phosphate transmembrane transporter activity; sodium-dependent phosphate transmembrane transporter activity; sodium:inorganic phosphate symporter activity
Biological Process: L-glutamate import; long-term memory; phosphate transport; regulation of excitatory postsynaptic membrane potential; sequestering of neurotransmitter; synaptic transmission; synaptic transmission, glutamatergic
Reference #:  Q3TXX4 (UniProtKB)
Alt. Names/Synonyms: 2900052E22Rik; AI851913; Bnpi; Brain-specific Na(+)-dependent inorganic phosphate cotransporter; Slc17a7; solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 7; Solute carrier family 17 member 7; Vesicular glutamate transporter 1; VGLU1; VGluT1
Gene Symbols: Slc17a7
Molecular weight: 61,637 Da
Basal Isoelectric point: 6.96  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

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