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KSR a serine/threonine kinase of the Raf family with no demonstrated kinase activity. A location-regulated scaffolding protein connecting MEK to RAF. Promotes MEK and RAF phosphorylation and activity through assembly of an activated signaling complex. Interacts with RAF and MAPK/ERK, in a Ras-dependent manner. The binding of 14-3-3 proteins to phosphorylated KSR prevents the membrane localization. In unstimulated cells, the phosphorylated form is bound to a 14-3-3 protein and sequestered in the cytoplasm. Translocates from the cytoplasm to the cell periphery following TNF treatment. When Bad is available, ceramide signaling through the Ras/Raf cascade can lead to apoptosis. Three alternatively-spliced isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL; RAF family; TKL group
Chromosomal Location of Human Ortholog: 17q11.2
Cellular Component: cytosol; endoplasmic reticulum; membrane; protein complex
Molecular Function: MAP-kinase scaffold activity; protein binding; protein C-terminus binding; protein kinase activity; signal transducer activity
Biological Process: cAMP-mediated signaling; MAPKKK cascade; positive regulation of MAPKKK cascade; protein amino acid phosphorylation; Ras protein signal transduction
Reference #:  Q8IVT5 (UniProtKB)
Alt. Names/Synonyms: kinase suppressor of ras; Kinase suppressor of Ras 1; KSR; KSR1; RSU2
Gene Symbols: KSR1
Molecular weight: 102,160 Da
Basal Isoelectric point: 8.94  Predict pI for various phosphorylation states
CST Pathways:  GPCR Signaling to MAPKs  |  Growth And Differentiation Control by MAPKs
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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