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IKBKAP May act as a scaffold protein that may assemble active IKK-MAP3K14 complexes (IKKA, IKKB and MAP3K14/NIK). Interacts preferentially with MAP3K14/NIK followed by IKK-alpha and IKK-beta. Component of the RNA polymerase II elongator complex (Elongator), which consists of IKBKAP/ELP1, STIP1/ELP2, ELP3, ELP4, and two yet unidentified proteins, p30 and p38. Elongator associates with the C-terminal domain (CTD) of Pol II largest subunit. Interacts with ELP3. Belongs to the ELP1/IKA1 family. Note: This description may include information from UniProtKB.
Protein type: Protein kinase, regulatory subunit; Transcription regulation
Chromosomal Location of Human Ortholog: 9q31.3
Cellular Component: cytoplasm; cytosol; Elongator holoenzyme complex; histone acetyltransferase complex; nucleolus; transcription elongation factor complex
Molecular Function: phosphorylase kinase regulator activity; protein binding; signal transducer activity
Biological Process: immune response; positive regulation of cell migration; protein amino acid phosphorylation; protein complex assembly; regulation of transcription from RNA polymerase II promoter; RNA elongation from RNA polymerase II promoter
Disease: Neuropathy, Hereditary Sensory And Autonomic, Type Iii
Reference #:  O95163 (UniProtKB)
Alt. Names/Synonyms: DKFZp781H1425; DYS; Elongator complex protein 1; ELP1; FD; FLJ12497; IKAP; IkappaB kinase complex-associated protein; IKBKAP; IKI3; IKK complex-associated protein; inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase complex-associated protein; p150; TOT1
Gene Symbols: IKBKAP
Molecular weight: 150,254 Da
Basal Isoelectric point: 5.61  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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