a TKL kinase of the IRAK family. The interleukin-1 receptor-associated kinases are important mediators in the signal transduction of Toll-like receptor and IL1R family members, collectively referred to as TIRs. Note: This description may include information from UniProtKB.
Protein type: EC 22.214.171.124; IRAK family; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL; TKL group
Molecular Function: ATP binding; magnesium ion binding; protein heterodimerization activity; protein homodimerization activity; protein serine/threonine kinase activity
Biological Process: activation of NF-kappaB transcription factor; cytokine and chemokine mediated signaling pathway; inhibition of NF-kappaB transcription factor; MyD88-dependent toll-like receptor signaling pathway; negative regulation of cytokine and chemokine mediated signaling pathway; negative regulation of innate immune response; negative regulation of interleukin-12 production; negative regulation of interleukin-6 production; negative regulation of MAP kinase activity; negative regulation of protein catabolic process; negative regulation of protein complex disassembly; negative regulation of toll-like receptor signaling pathway; negative regulation of tumor necrosis factor production; protein amino acid phosphorylation; regulation of protein complex disassembly; response to exogenous dsRNA; response to lipopolysaccharide; response to peptidoglycan; response to virus