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Protein Page:

SCAI Tumor suppressor which functions to suppress MKL1- induced SRF transcriptional activity. May function in the RHOA- DIAPH1 signal transduction pathway and regulate cell migration through transcriptional regulation of ITGB1. Belongs to the SCAI family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Transcription, coactivator/corepressor
Chromosomal Location of Human Ortholog: 9q33.3
Cellular Component: nuclear membrane; nucleoplasm; nucleus
Molecular Function: protein binding; transcription corepressor activity
Biological Process: negative regulation of cell migration; negative regulation of Rho protein signal transduction
Reference #:  Q8N9R8 (UniProtKB)
Alt. Names/Synonyms: C9orf126; FLJ11758; FLJ36664; MGC120525; MGC120526; MGC120528; NET40; Protein SCAI; SCAI; suppressor of cancer cell invasion; Suppressor of cancer cell invasion protein
Gene Symbols: SCAI
Molecular weight: 70,399 Da
Basal Isoelectric point: 8.78  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

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