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SIRT2 NAD-dependent protein deacetylase, which deacetylates internal lysines on histone and non-histone proteins. Deacetylates 'Lys-40' of alpha-tubulin. Involved in the control of mitotic exit in the cell cycle, probably via its role in the regulation of cytoskeleton. Deacetylates PCK1, opposing proteasomal degradation. Deacetylates 'Lys-310' of RELA. Interacts with HDAC6, suggesting that these proteins belong to a large complex that deacetylate the cytoskeleton. Widely expressed. Highly expressed in heart, brain and skeletal muscle, while it is weakly expressed in placenta and lung. Down-regulated in many gliomas suggesting that it may act as a tumor suppressor gene in human gliomas possibly through the regulation of microtubule network. Inhibited by Sirtinol, A3 and M15 small molecules. Inhibited by nicotinamide. Belongs to the sirtuin family. Class I subfamily. 4 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Deacetylase; EC 3.5.1.-
Chromosomal Location of Human Ortholog: 19q13.2
Cellular Component: centriole; centrosome; chromosome; cytoplasm; cytosol; lateral loop; microtubule; midbody; myelin sheath; nuclear heterochromatin; nucleolus; nucleus; paranode region of axon; perikaryon; perinuclear region of cytoplasm; plasma membrane; spindle
Molecular Function: chromatin binding; histone acetyltransferase binding; histone deacetylase activity; histone deacetylase binding; NAD+ ADP-ribosyltransferase activity; NAD-dependent histone deacetylase activity; NAD-dependent histone deacetylase activity (H4-K16 specific); protein binding; protein deacetylase activity; transcription factor binding; tubulin deacetylase activity; ubiquitin binding; zinc ion binding
Biological Process: cellular lipid catabolic process; hepatocyte growth factor receptor signaling pathway; histone deacetylation; myelination in the peripheral nervous system; negative regulation of autophagy; negative regulation of cell proliferation; negative regulation of fat cell differentiation; negative regulation of protein catabolic process; negative regulation of striated muscle development; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; phosphoinositide 3-kinase cascade; positive regulation of attachment of spindle microtubules to kinetochore; positive regulation of cell division; positive regulation of DNA binding; positive regulation of meiosis; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; positive regulation of transcription from RNA polymerase II promoter; proteasomal ubiquitin-dependent protein catabolic process; protein amino acid ADP-ribosylation; protein amino acid deacetylation; protein kinase B signaling cascade; regulation of cell cycle; regulation of myelination; substantia nigra development
Reference #:  Q8IXJ6 (UniProtKB)
Alt. Names/Synonyms: NAD-dependent deacetylase sirtuin-2; silencing information regulator 2-like; silent information regulator 2; SIR2; SIR2-like protein 2; sir2-related protein type 2; SIR2L; SIR2L2; SIRT2; sirtuin (silent mating type information regulation 2 homolog) 2 (S. cerevisiae); sirtuin type 2
Gene Symbols: SIRT2
Molecular weight: 43,182 Da
Basal Isoelectric point: 5.22  Predict pI for various phosphorylation states
CST Pathways:  Apoptosis Regulation  |  Mitochondrial Control of Apoptosis  |  Protein Acetylation
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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