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DNAJC3 Involved in the unfolded protein response (UPR) during ER stress. Co-chaperone of HSPA8/HSC70, it stimulates its ATPase activity. May inhibit both the autophosphorylation of EIF2AK2/PKR and the ability of EIF2AK2 to catalyze phosphorylation of the EIF2A. May inhibit EIF2AK3/PERK activity. Interacts with EIF2AK3 and EIF2AK2. Forms a trimeric complex with DNAJB1 and HSPA8. Interacts with PRKRIR/P52RIPK. Up-regulated during an endoplasmic reticulum stress via ATF6. Activated in response to infection by influenza virus through the dissociation of DNAJB1. Down-regulated by DNAJB1 and PRKRIR/P52RIPK. Widely expressed with high level in the pancreas and testis. Also expressed in cell lines with different levels. Note: This description may include information from UniProtKB.
Protein type: Chaperone; Endoplasmic reticulum; Inhibitor; Protein kinase, regulatory subunit
Chromosomal Location of Human Ortholog: 13q32.1
Cellular Component: cytoplasm; cytosol; endoplasmic reticulum; endoplasmic reticulum lumen; extracellular region; membrane
Molecular Function: protein kinase binding; protein kinase inhibitor activity
Biological Process: cellular protein metabolic process; negative regulation of apoptosis; neutrophil degranulation; post-translational protein modification
Disease: Ataxia, Combined Cerebellar And Peripheral, With Hearing Loss And Diabetes Mellitus
Reference #:  Q13217 (UniProtKB)
Alt. Names/Synonyms: DnaJ (Hsp40) homolog, subfamily C, member 3; DnaJ homolog subfamily C member 3; DNAJC3; DNJC3; FLJ21288; HP58; Interferon-induced, double-stranded RNA-activated protein kinase inhibitor; P58; P58IPK; PRKRI; Protein kinase inhibitor of 58 kDa; Protein kinase inhibitor p58; protein-kinase, interferon-inducible double stranded RNA dependent inhibitor
Gene Symbols: DNAJC3
Molecular weight: 57,580 Da
Basal Isoelectric point: 5.83  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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