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MSX1 Acts as a transcriptional repressor. May play a role in limb-pattern formation. Acts in cranofacial development and specifically in odontogenesis. Expression in the developing nail bed mesenchyme is important for nail plate thickness and integrity. Expressed in the developing nail bed mesenchyme. Belongs to the Msh homeobox family. Note: This description may include information from UniProtKB.
Protein type: DNA-binding; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 4p16.2
Cellular Component: nucleoplasm; nucleus
Molecular Function: p53 binding
Biological Process: cell morphogenesis; negative regulation of cell growth; odontogenesis of dentine-containing teeth; positive regulation of DNA damage response, signal transduction by p53 class mediator; protein stabilization
Disease: Orofacial Cleft 5; Tooth Agenesis, Selective, 1; Witkop Syndrome
Reference #:  P28360 (UniProtKB)
Alt. Names/Synonyms: homeobox 7; Homeobox protein Hox-7; Homeobox protein MSX-1; HOX7; HYD1; msh homeo box 1; msh homeobox 1; Msh homeobox 1-like protein; msh homeobox homolog 1; MSX1; STHAG1
Gene Symbols: MSX1
Molecular weight: 31,496 Da
Basal Isoelectric point: 9.89  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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