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SCF Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. KITLG/SCF binding can activate several signaling pathways. Promotes phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, and subsequent activation of the kinase AKT1. KITLG/SCF and KIT also transmit signals via GRB2 and activation of RAS, RAF1 and the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1. KITLG/SCF and KIT promote activation of STAT family members STAT1, STAT3 and STAT5. KITLG/SCF and KIT promote activation of PLCG1, leading to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5- trisphosphate. KITLG/SCF acts synergistically with other cytokines, probably interleukins. Homodimer, non-covalently linked (Probable). Heterotetramer with KIT, binding two KIT molecules; thereby mediates KIT dimerization and subsequent activation by autophosphorylation. Belongs to the SCF family. 3 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral
Chromosomal Location of Human Ortholog: 10 D1|10 51.4 cM
Cellular Component: cytoplasm; extracellular space; filopodium; integral to membrane; lamellipodium; plasma membrane
Molecular Function: cytokine activity; protein binding; stem cell factor receptor binding
Biological Process: embryonic hemopoiesis; germ cell development; germ cell programmed cell death; negative regulation of apoptosis; negative regulation of mast cell apoptosis; neural crest cell migration; ovarian follicle development; positive regulation of cell proliferation; positive regulation of DNA replication; positive regulation of leukocyte migration; positive regulation of MAP kinase activity; positive regulation of melanocyte differentiation; positive regulation of myeloid leukocyte differentiation; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of Ras protein signal transduction
Reference #:  P20826 (UniProtKB)
Alt. Names/Synonyms: c-Kit ligand; Clo; cloud gray; Con; contrasted; Gb; grizzle-belly; Hematopoietic growth factor KL; Kit ligand; Kitl; Kitlg; Mast cell growth factor; MGF; OTTMUSP00000022753; SCF; SF; Sl; Slf; Steel; Steel factor; Stem cell factor
Gene Symbols: Kitlg
Molecular weight: 30,645 Da
Basal Isoelectric point: 5.28  Predict pI for various phosphorylation states
CST Pathways:  G1/S Checkpoint  |  G2/M DNA Damage Checkpoint
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Protein Structure Not Found.
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