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ROS a proto-oncogenic receptor tyrosine kinase whose expression is tightly restricted during development. Normally expressed in adult murine and human epithelial cells of the epididymis. Transgenic mice lacking the c-ros gene are infertile. Ectopic expression of c-Ros has been reported in meningiomas and astrocytomas. Is up-regulated in human glioma: 30% of malignant glioma tumors are ROS positive. An oncogenic fusion protein between PIST (aka FIG) and ROS, resulting from an intra-chromosomal homozygous deletion of 240 kilobases on 6q21, is found in glioblastoma multiform. PIST (aka FIG) is a peripheral membrane protein associated with the Golgi apparatus. Unlike other fusion RTK oncogenes, the mechanism of activation of PIST-ROS does not appear to be dimerization: the PIST-ROS fusion protein appears to be monomeric in vivo. Rather, activation of the fused ROS kinase appears to depend upon translocation to the golgi apparatus: deletion of 2nd coiled-coil region of PIST, crucial for Golgi localization, appears to eliminate the transformation capacity of PIST-ROS. c-ROS may also be activated epigenetically, suggesting caution when using 5-aza-dC for treating glioma. Note: This description may include information from UniProtKB.
Protein type: EC; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor); Sev family; TK group
Chromosomal Location of Human Ortholog: 6q22.1
Cellular Component: membrane
Molecular Function: protein binding; protein phosphatase binding; protein-tyrosine kinase activity
Biological Process: cell differentiation; cell growth; cell proliferation; columnar/cuboidal epithelial cell development; protein amino acid phosphorylation; regulation of TOR signaling pathway; spermatogenesis
Reference #:  P08922 (UniProtKB)
Alt. Names/Synonyms: c-ros oncogene 1 , receptor tyrosine kinase; c-ros-1; MCF3; proto-oncogene c-ros-1 protein; Proto-oncogene tyrosine-protein kinase ROS; ROS; ROS1; transmembrane tyrosine-specific protein kinase; v-ros avian UR2 sarcoma virus oncogene homolog 1; v-ros UR2 sarcoma virus oncogene homolog 1
Gene Symbols: ROS1
Molecular weight: 263,915 Da
Basal Isoelectric point: 5.76  Predict pI for various phosphorylation states
CST Pathways:  Tyrosine Kinases & Substrates
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