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RRAGB Has guanine nucleotide-binding activity but undetectable intrinsic GTPase activity. Required for the amino acid-induced relocalization of mTORC1 to the lysosomes and its subsequent activation by the GTPase RHEB. This is a crucial step in the activation of the TOR signaling cascade by amino acids. Involved in the RCC1/Ran-GTPase pathway. Involved in the RCC1/Ran-GTPase pathway. The short isoform binds GTP. Interacts with RRAGC and RRAGD. Belongs to the GTR/RAG GTP-binding protein family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Chromosomal Location of Human Ortholog: Xp11.21
Cellular Component: cytoplasm; cytosol; lysosomal membrane; lysosome; nucleus
Molecular Function: GTP binding; GTPase activity; GTPase binding; guanyl ribonucleotide binding; protein binding; protein heterodimerization activity
Biological Process: cell cycle arrest; cellular response to amino acid starvation; positive regulation of TOR signaling pathway; regulation of autophagy; regulation of macroautophagy; regulation of TOR signaling pathway
Reference #:  Q5VZM2 (UniProtKB)
Alt. Names/Synonyms: bA465E19.1; GTP-binding protein ragB; Rag B; RagB; Ras-related GTP binding B; Ras-related GTP-binding protein B; RRAGB
Gene Symbols: RRAGB
Molecular weight: 43,250 Da
Basal Isoelectric point: 5.85  Predict pI for various phosphorylation states
CST Pathways:  mTOR Signaling  |  Translation: eIF4E and p70S6K
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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