Has guanine nucleotide-binding activity but undetectable intrinsic GTPase activity. Required for the amino acid-induced relocalization of mTORC1 to the lysosomes and its subsequent activation by the GTPase RHEB. This is a crucial step in the activation of the TOR signaling cascade by amino acids. Involved in the RCC1/Ran-GTPase pathway. Involved in the RCC1/Ran-GTPase pathway. The short isoform binds GTP. Interacts with RRAGC and RRAGD. Belongs to the GTR/RAG GTP-binding protein family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Molecular Function: GTP binding; GTPase activity; GTPase binding; guanyl ribonucleotide binding; protein binding; protein heterodimerization activity
Biological Process: cell cycle arrest; cellular response to amino acid starvation; positive regulation of TOR signaling pathway; regulation of autophagy; regulation of macroautophagy; regulation of TOR signaling pathway