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Ron a receptor tyrosine kinase of the Met family. Receptor for macrophage stimulating protein. Can be desensitized by c-Cbl and its binding partner Grb2. Overexpression of wild-type RON causes the formation of lung tumors. Two alternatively spliced isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: EC; Kinase, protein; Membrane protein, integral; Met family; Protein kinase, TK; Protein kinase, tyrosine (receptor); TK group
Chromosomal Location of Human Ortholog: 3p21.31
Cellular Component: cell surface; integral component of plasma membrane; plasma membrane; stress fiber; vacuole
Molecular Function: ATP binding; enzyme binding; macrophage colony-stimulating factor receptor activity; protein binding
Biological Process: cell motility; defense response; hepatocyte growth factor receptor signaling pathway; innate immune response; macrophage colony-stimulating factor signaling pathway; peptidyl-tyrosine phosphorylation; positive regulation of cell proliferation; positive regulation of MAP kinase activity; positive regulation of protein kinase B signaling; response to virus; signal transduction; single fertilization
Disease: Nasopharyngeal Carcinoma, Susceptibility To, 3
Reference #:  Q04912 (UniProtKB)
Alt. Names/Synonyms: c-met-related tyrosine kinase; CD136; CDw136; macrophage stimulating 1 receptor (c-met-related tyrosine kinase); Macrophage-stimulating protein receptor; Macrophage-stimulating protein receptor alpha chain; Macrophage-stimulating protein receptor beta chain; MSP receptor; MST1R; p185-Ron; Protein-tyrosine kinase 8; PTK8; PTK8 protein tyrosine kinase 8; RON; soluble RON variant 1; soluble RON variant 2; soluble RON variant 3; soluble RON variant 4
Gene Symbols: MST1R
Molecular weight: 152,271 Da
Basal Isoelectric point: 6.09  Predict pI for various phosphorylation states
CST Pathways:  Tyrosine Kinases & Substrates
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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