Involved in the costimulatory signal, essential for T- cell proliferation and production of IL10 and IFNG, in an IL2- dependent and a PDCD1-independent manner. Interaction with PDCD1 inhibits T-cell proliferation and cytokine production. Belongs to the immunoglobulin superfamily. BTN/MOG family. 3 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Cellular Component: cell surface; external side of plasma membrane; integral component of membrane; membrane; plasma membrane
Molecular Function: protein binding
Biological Process: cell surface receptor signaling pathway; immune response; negative regulation of activated T cell proliferation; negative regulation of interferon-gamma production; negative regulation of interleukin-10 production; negative regulation of T cell proliferation; positive regulation of cell migration; positive regulation of T cell proliferation; response to cytokine; signal transduction; T cell costimulation