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PD-L1 Involved in the costimulatory signal, essential for T- cell proliferation and production of IL10 and IFNG, in an IL2- dependent and a PDCD1-independent manner. Interaction with PDCD1 inhibits T-cell proliferation and cytokine production. Belongs to the immunoglobulin superfamily. BTN/MOG family. 3 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral
Chromosomal Location of Human Ortholog: 9p24.1
Cellular Component: endomembrane system; external side of plasma membrane; integral component of membrane; plasma membrane
Molecular Function: protein binding
Biological Process: cell surface receptor signaling pathway; immune response; negative regulation of activated T cell proliferation; negative regulation of interferon-gamma production; negative regulation of interleukin-10 production; positive regulation of cell migration; positive regulation of T cell proliferation; regulation of activated T cell proliferation; response to cytokine; signal transduction; T cell costimulation
Reference #:  Q9NZQ7 (UniProtKB)
Alt. Names/Synonyms: B7 homolog 1; B7-H; B7-H1; B7H1; CD274; CD274 antigen; CD274 molecule; MGC142294; MGC142296; PD-L1; PD1L1; PDCD1 ligand 1; PDCD1L1; PDCD1LG1; PDL1; Programmed cell death 1 ligand 1; Programmed death ligand 1
Gene Symbols: CD274
Molecular weight: 33,275 Da
Basal Isoelectric point: 6.76  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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