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dectin-1 Lectin that functions as pattern receptor specific for beta-1,3-linked and beta-1,6-linked glucans, such as cell wall constituents from pathogenic bacteria and fungi. Necessary for the TLR2-mediated inflammatory response and for TLR2-mediated activation of NF-kappa-B. Enhances cytokine production in macrophages and dendritic cells. Mediates production of reactive oxygen species in the cell. Mediates phagocytosis of C.albicans conidia. Binds T-cells in a way that does not involve their surface glycans and plays a role in T-cell activation. Stimulates T-cell proliferation. Up-regulated during differentiation from monocytes into dendritic cells. Isoform 5 interacts with RANBP9. 8 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral
Chromosomal Location of Human Ortholog: 12p13.2
Cellular Component: integral to membrane; intracellular membrane-bound organelle; nucleoplasm; plasma membrane
Molecular Function: carbohydrate binding; pattern recognition receptor activity; protein binding
Biological Process: carbohydrate mediated signaling; cell recognition; phagocytosis, recognition; stimulatory C-type lectin receptor signaling pathway; T cell activation
Disease: Aspergillosis, Susceptibility To; Candidiasis, Familial, 4
Reference #:  Q9BXN2 (UniProtKB)
Alt. Names/Synonyms: Beta-glucan receptor; BGR; C-type (calcium dependent, carbohydrate-recognition domain) lectin, superfamily member 12; C-type lectin domain family 7 member A; C-type lectin domain family 7, member A; C-type lectin superfamily member 12; CANDF4; CLC7A; CLEC7A; CLECSF12; DC-associated C-type lectin 1; Dectin-1; DECTIN1; Dendritic cell-associated C-type lectin 1; dendritic cell-associated C-type lectin-1; lectin-like receptor 1
Gene Symbols: CLEC7A
Molecular weight: 27,627 Da
Basal Isoelectric point: 5.21  Predict pI for various phosphorylation states
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