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RECK Negatively regulates matrix metalloproteinase-9 (MMP-9) by suppressing MMP-9 secretion and by direct inhibition of its enzymatic activity. RECK down-regulation by oncogenic signals may facilitate tumor invasion and metastasis. Appears to also regulate MMP-2 and MT1-MMP, which are involved in cancer progression. Interacts with MMP-9. Expressed in various tissues and untransformed cells. It is undetectable in tumor-derived cell lines and oncogenically transformed cells. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, GPI anchor; Tumor suppressor
Chromosomal Location of Human Ortholog: 9p13.3
Cellular Component: extracellular region; membrane; plasma membrane
Molecular Function: endopeptidase inhibitor activity; metalloendopeptidase inhibitor activity; protein binding
Biological Process: C-terminal protein lipidation; negative regulation of cell migration
Reference #:  O95980 (UniProtKB)
Alt. Names/Synonyms: hRECK; membrane-anchored glycoprotein (metastasis and invasion); RECK; Reversion-inducing cysteine-rich protein with Kazal motifs; reversion-inducing-cysteine-rich protein with kazal motifs; ST15; suppression of tumorigenicity 15 (reversion-inducing-cysteine-rich protein with kazal motifs); suppression of tumorigenicity 5 (reversion-inducing-cysteine-rich protein with kazal motifs); Suppressor of tumorigenicity 15 protein
Gene Symbols: RECK
Molecular weight: 106,457 Da
Basal Isoelectric point: 6.35  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

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