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LCMT1 Methylates the carboxyl group of the C-terminal leucine residue of protein phosphatase 2A catalytic subunits to form alpha-leucine ester residues. Belongs to the methyltransferase superfamily. LCMT family. 3 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Amino Acid Metabolism - histidine; Amino Acid Metabolism - tyrosine; EC; Lipid Metabolism - androgen and estrogen; Methyltransferase; Other Amino Acids Metabolism - selenoamino acid
Chromosomal Location of Human Ortholog: 7|7 F3
Cellular Component: cytosol
Molecular Function: C-terminal protein carboxyl methyltransferase activity; protein methyltransferase activity; protein-leucine O-methyltransferase activity
Biological Process: C-terminal protein amino acid methylation; negative regulation of protein complex assembly; protein amino acid methylation; regulation of apoptosis
Reference #:  A2RTH5 (UniProtKB)
Alt. Names/Synonyms: AL033290; Lcmt; LCMT-1; Lcmt1; Leucine carboxyl methyltransferase 1; Leucine carboxyl methyltransferase 1, isoform CRA_b; MGC11807
Gene Symbols: Lcmt1
Molecular weight: 38,192 Da
Basal Isoelectric point: 5.44  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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