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EphA4 a tyrosine kinase receptor of the Eph family. Receptor for members of the ephrin-A family. Binds to ephrin-A1, -A4 and -A5. Binds more poorly to ephrin-A2 and -A3. May play a role in hindbrain pattern formation. The Eph receptor tyrosine kinase family, the largest in the tyrosine kinase group, has fourteen members. They bind membrane-anchored ligands, ephrins, at sites of cell-cell contact, regulating the repulsion and adhesion of cells that underlie the establishment, maintenance, and remodeling of patterns of cellular organization. Eph signals are particularly important in regulating cell adhesion and cell migration during development, axon guidance, homeostasis and disease. EphA receptors bind to GPI-anchored ephrin-A ligands, while EphB receptors bind to ephrin-B proteins that have a transmembrane and cytoplasmic domain. Interactions between EphB receptor kinases and ephrin-B proteins transduce signals bidirectionally, signaling to both interacting cell types. Eph receptors and ephrins also regulate the adhesion of endothelial cells and are required for the remodeling of blood vessels. Note: This description may include information from UniProtKB.
Protein type: EC; Eph family; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor); TK group
Chromosomal Location of Human Ortholog: 2q36.1
Cellular Component: axon; cytoplasm; dendrite; dendritic shaft; dendritic spine; early endosome membrane; integral to plasma membrane; plasma membrane
Molecular Function: GPI-linked ephrin receptor activity; PH domain binding; protein binding; protein kinase activity; transmembrane-ephrin receptor activity
Biological Process: corticospinal tract morphogenesis; ephrin receptor signaling pathway; motor axon guidance; negative regulation of axon regeneration; peptidyl-tyrosine phosphorylation; protein amino acid autophosphorylation; regulation of astrocyte differentiation; regulation of axonogenesis; regulation of GTPase activity
Reference #:  P54764 (UniProtKB)
Alt. Names/Synonyms: EK8; EPH receptor A4; EPH-like kinase 8; EPHA4; ephrin receptor EphA4; Ephrin type-A receptor 4; HEK8; receptor protein-tyrosine kinase HEK8; SEK; TYRO1; TYRO1 protein tyrosine kinase; Tyrosine-protein kinase receptor SEK; Tyrosine-protein kinase TYRO1
Gene Symbols: EPHA4
Molecular weight: 109,860 Da
Basal Isoelectric point: 6.21  Predict pI for various phosphorylation states
CST Pathways:  Tyrosine Kinases & Substrates
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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