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KLHL12 Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a negative regulator of Wnt signaling pathway and ER-Golgi transport. The BCR(KLHL12) complex is involved in ER-Golgi transport by regulating the size of COPII coats, thereby playing a key role in collagen export, which is required for embryonic stem (ES) cells division: BCR(KLHL12) acts by mediating monoubiquitination of SEC31 (SEC31A or SEC31B). As part of the BCR(KLHL12) complex, also acts as a negative regulator of the Wnt signaling pathway by mediating ubiquitination and subsequent proteolysis of DVL3. The BCR(KLHL12) complex also mediates polyubiquitination of DRD4, without leading to degradation of DRD4. Component of the BCR(KLHL12) E3 ubiquitin ligase complex, at least composed of CUL3 and KLHL12 and RBX1. This complex interacts with DVL3 upon activation of the Wnt signaling pathway by WNT3A. Interacts with DRD4, KLHL12 and SEC31A. Ubiquitously expressed. Highly expressed in testis and at lower levels in the submandibular salivary gland. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Ubiquitin conjugating system
Chromosomal Location of Human Ortholog: 1q32.1
Cellular Component: COPII vesicle coat; cytosol; ER to Golgi transport vesicle; intracellular membrane-bound organelle; microtubule organizing center
Molecular Function: identical protein binding; protein binding; ubiquitin-protein ligase activity
Biological Process: COPII coating of Golgi vesicle; ER to Golgi vesicle-mediated transport; neural crest cell development; neural crest formation; protein monoubiquitination; Wnt receptor signaling pathway
Reference #:  Q53G59 (UniProtKB)
Alt. Names/Synonyms: C3IP1; CUL3-interacting protein 1; DKIR; FLJ27152; kelch-like 12 (Drosophila); Kelch-like protein 12; kelch-like protein C3IP1; KLH12; KLHL12
Gene Symbols: KLHL12
Molecular weight: 63,277 Da
Basal Isoelectric point: 5.26  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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