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TIMP3 Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. May form part of a tissue-specific acute response to remodeling stimuli. Known to act on MMP-1, MMP-2, MMP-3, MMP-7, MMP-9, MMP-13, MMP-14 and MMP-15. Interacts with EFEMP1. Belongs to the protease inhibitor I35 (TIMP) family. Note: This description may include information from UniProtKB.
Protein type: Motility/polarity/chemotaxis; Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 22q12.3
Cellular Component: extracellular matrix; extracellular region; extracellular space; nucleus; proteinaceous extracellular matrix
Molecular Function: metalloendopeptidase inhibitor activity; protease binding; protein binding
Biological Process: negative regulation of membrane protein ectodomain proteolysis; platelet degranulation; response to organic substance
Disease: Fundus Dystrophy, Pseudoinflammatory, Of Sorsby
Reference #:  P35625 (UniProtKB)
Alt. Names/Synonyms: HSMRK222; K222; K222TA2; Metalloproteinase inhibitor 3; MIG-5 protein; Protein MIG-5; SFD; TIMP metallopeptidase inhibitor 3; TIMP-3; TIMP3; Tissue inhibitor of metalloproteinases 3
Gene Symbols: TIMP3
Molecular weight: 24,145 Da
Basal Isoelectric point: Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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